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What does Accutane do?
Accutane is a life-changing medication that can treat moderate to severe acne vulgaris that has failed to respond to other treatments, such as topical and oral antibiotics, topical tretinoin, and over-the-counter acne products such as salicylic acid, glycolic acid, and benzoyl peroxide. In the past, Accutane used to be considered a “last resort” treatment option when all other treatments failed. Accutane is now commonly prescribed to treat all types and severity of acne and prevent future acne breakouts and new acne scars from forming. Accutane effectively combats all types of breakouts, whether cysts, nodules, pustules, pimples, whiteheads, or blackheads. Many patients report that their acne was permanently cured after completing one course of Accutane, or at the very least, acne-free for many years.
How does Accutane work?
The exact mechanism of Accutane is not entirely known. Still, it is believed that its mechanism of action induces apoptosis, or programmed cell death, in the sebaceous glands to reduce the inflammation and bacteria that live in the follicle. This process allows the skin to heal and blocks the formation of new acne lesions. In addition to apoptosis, Accutane reduces sebum production and has an antimicrobial effect on certain acne-causing skin bacteria. Accutane also increases the rate of skin cell turnover to make dead skin cells less able to form comedowns (blackheads and whiteheads). These various mechanisms of action work in unison to create a more permanent “cure” for acne, including severe cystic acne.
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